Builders trade speed for weight
Enormously faster to launch and to change without a developer. The cost is page weight, deep plugin lock-in and markup that is difficult to migrate away from.
Hand-built themes trade flexibility for control
Lighter, faster and more predictable, at the price of needing a developer for changes a builder would let a marketer make in minutes.
The question that decides it
Who edits this site weekly? If the answer is a non-developer, a builder usually wins despite the weight — the alternative is changes that never get made.